Meryem Topal

Design, Synthesis, and X-ray Characterization of Benzohydrazide Derivatives as Cholinesterase Inhibitors for the Treatment of Alzheimer’s Disease: An Experimental and Computational Approach to Biological Activity

In this study, a series of new benzohydrazide derivatives (1a-i) were synthesized, and characterized as potential cholinesterase inhibitors for use in the treatment of Alzheimer’s disease (AD). The inhibitory activities of the synthesized compounds against acetylcholinesterase (A...

Relationship of chronotype, biological rhythm characteristics and sleep quality with suicidal behavior in patients with opioid use disorder

Opioid Use Disorder (OUD) carries a high risk of psychiatric comorbidities, such as depression, sleep disturbances and suicidal behaviour. Recent findings emphasise the impact of chronotype and biological rhythm disturbances on the severity of addiction and suicidality. This stud...