Mengyan Chen

PHPT1/Ocnus negatively regulates the JAK/STAT pathway to control cell survival

The JAK/STAT signaling pathway is a highly conserved regulator essential for animal development. Here, we show that the Drosophila phosphohistidine phosphatase 1, PHPT1/Ocnus, is required for cell survival by regulating JAK/STAT signaling. Knockdown of ocnus ( ocn ) leads to apop...