Mengfei Yu

The role of N6-methyladenosine (m6A) modification in the development and progression of head and neck squamous cell carcinoma (HNSCC): mechanistic insights and translational challenges

Head and neck squamous cell carcinoma (HNSCC) ranks as the sixth most prevalent malignancy worldwide, encompassing tumors derived from the mucosal epithelia of the oral cavity, pharynx, larynx and other head and neck regions. Most patients are diagnosed at an advanced stage due t...

Engineering Biomimetic Tumor Organoids Inspired by Janus Stiffness–Driven Cell Stemness

ABSTRACT Organoids become powerful platforms for modeling cancer biology but poorly preserve stemness due to inadequate biophysical cues. Cancer stem cells (CSCs), crucial for tumor growth, are rare and lose stemness under conventional in vitro conditions, limiting drug screening...