Meijing Yi

Perineural invasion in hepatocellular carcinoma: clinical evidence and mechanistic hypotheses

Hepatocellular carcinoma (HCC) is a major cause of cancer mortality worldwide. Emerging evidence in cancer neuroscience suggests that tumor–nerve crosstalk can modulate tumor growth, immune remodeling, dissemination, and therapy resistance. Perineural invasion (PNI) is a hallmark...