Mei Li

Genotype and phenotypic spectrum of pycnodysostosis: report of a case harboring two novel CTSK variants and literature review

Abstract Background Pycnodysostosis is an extremely rare inherited skeletal dysplasia with incidence of about 1 to 1.7 per million neonates. We reported a patient with pycnodysostosis, who had typical craniofacial deformity, short stature and recurrent limb fracture history. Lite...

Huangqi Guizhi Wuwu Decoction Ameliorates Cachexia in Lung Cancer Mice Through Regulating Amino Acid Metabolism: Insights From Transcriptomics, Metabolomics and Experimental Validation

ABSTRACT The effects and mechanisms of Huangqi Guizhi Wuwu Decoction (HGWD) in cancer cachexia remain unclear. We generated an in vivo cachexia model by implanting Lewis lung carcinoma cells into mice and treated animals with HGWD. We evaluated muscle function using grip strength...