Mehdi Goudarzi

Effects of simultaneous co-treatment with a de novo cationic antimicrobial peptide and silver nanoparticles on biofilm biomass and lasR, algD, and tpbB gene expression in Pseudomonas aeruginosa

Abstract Pseudomonas aeruginosa is a major opportunistic and multidrug-resistant pathogen associated with chronic biofilm-related infections. This study aimed to design a de novo cationic antimicrobial peptide and evaluate its combined effects with silver nanoparticles (AgNPs) on...

Global prevalence of colistin resistance, mcr gene variants, and sequence types in Pseudomonas aeruginosa, Klebsiella pneumoniae, Escherichia coli, and Stenotrophomonas maltophilia: a systematic review and meta-analysis

Abstract Background Due to the increasing prevalence of infections caused by multidrug-resistant (MDR) Gram-negative bacteria, colistin has become an important therapeutic option. However, the rapid emergence of resistance to this antimicrobial agent, mediated by mechanisms such...