Mayukh Guha

SPEF1 mediates assembly of central pair microtubule complexes in cilia of Tetrahymena

SPEF1 is a conserved calponin-homology domain protein that decorates the seam of central pair microtubules in the distal segment of motile cilia. Here, we show that in the ciliate Tetrahymena, loss of SPEF1 disrupts the central pair throughout the middle segment, which comprises...