Maurizio Cutolo

Induction of a non-inflammatory macrophage phenotype M2 (CD206⁺MerTK⁺) by prednisolone and CTLA4-Ig (abatacept) combined treatment in cultured monocyte-derived macrophages from early diagnosed rheumatoid arthritis patients

Macrophages play crucial and bivalent roles in active and remission phases of synovitis in rheumatoid arthritis (RA). Glucocorticoids, usually prednisolone (PD), represent part of the first line of treatment in early RA. Therefore, conventional and then biological disease modifyi...

Cancer in systemic sclerosis: clinical associations and prognostic impact from the EUSTAR registry

BACKGROUND: Cancer represents a major cause of mortality in systemic sclerosis (SSc). Established risk factors are limited to specific subsets, particularly early diffuse anti-RNA polymerase III (POLR3)-positive disease, needing further exploration. METHODS: We performed a nested...