Maurizia Rossana Brunetto

Comparative Prognostic Value of AFP, PIVKA-II, and GPC-3 in Hepatocellular Carcinoma: A Real-World Multicenter Cohort Study

Background/Objectives: The current cornerstone for prognostic hepatocellular carcinoma (HCC) stratification is the Barcelona Clinic Liver Cancer (BCLC) score, which integrates tumor and liver function staging but lacks tumor biology parameters. Serum tumor biomarkers, such as alp...

High rates of transition to immune active disease in a cohort of strictly defined immune tolerant patients with chronic hepatitis B: results from the RADICAL consortium

Background Patients with immune tolerant (IT) chronic hepatitis B (CHB) have high viral loads, minimal inflammation and minimal fibrosis. Nevertheless, the benign nature of this phase and the need for antiviral therapy remain controversial. Objective We explored the natural histo...