Maurício Homem-de-Mello

A large-scale in silico chimera-based strategy for engineering low-immunogenic L-asparaginase from Penicillium cerradense

L-asparaginase (L-ASNase) is an amidohydrolase with high therapeutic value for the treatment of acute lymphoblastic leukemia (ALL). However, its clinical application is limited by immunogenicity, allergenicity, and adverse effects from glutaminase activity. In this study, we engi...