Mattias Johansson

Large-scale association study identifies lung cancer susceptibility copy number variants and their potential functional role in genetic instability

BACKGROUND: Genome-wide association studies (GWAS) have identified numerous lung cancer susceptibility loci based on single nucleotide polymorphisms (SNPs), yet a substantial proportion of heritability remains unexplained. We therefore evaluated germline copy number variants (CNV...

Analysis of the Potential Mediating Role of Plasma Proteins in the Association Between Air Pollution Exposure and Lung Cancer Risk Among Ever-Smokers

Abstract The biological mechanisms linking air pollution to lung carcinogenesis remain underexplored. This study aimed to identify key proteins and pathways involved in mediating the effects of air pollutants on lung cancer risk. We analyzed 95 matched lung cancer case–control pa...