Mattia Giovannini

Emerging therapeutic strategies and clinical trials in severe asthma management: current evidence and future directions

Introduction Biologic therapies have transformed the management of severe asthma, particularly in type 2-high disease, but important unmet needs remain. Incomplete responses, uncertainty in treatment positioning, and the lack of effective options for non-type 2 or mixed inflammat...

Innovative positioning of respiratory allergen immunotherapy: a focus on precision medicine

Introduction Allergen immunotherapy (AIT) is the only treatment for IgE-mediated respiratory allergy that can modify disease progression. Historically, AIT has relied on empirical personalization, based on allergen selection and clinical judgment. However, AIT is now transitionin...

Exploring the potential benefits of allergen immunotherapy beyond respiratory allergy

INTRODUCTION: Allergen immunotherapy (AIT) is the only disease-modifying treatment for IgE-mediated allergic disorders, including allergic rhinitis and asthma, with established long-term clinical efficacy and immunological tolerance induction. AREAS COVERED: This review synthesiz...