Matthijs Kox

Interferon-enhanced cytokine responsiveness in early trauma-induced immune dysfunction: a prospective observational pilot study

Severe trauma induces profound alterations in innate and adaptive immunity within hours after injury, which may contribute to increased susceptibility to secondary infections and adverse outcomes. While trauma-associated immune dysfunction has been extensively described, little i...

Systemic inflammation is associated with increased cerebrospinal fluid CRP and may affect meningitis diagnostics

C-reactive protein (CRP) in cerebrospinal fluid (CSF) has been proposed as a highly specific diagnostic marker for bacterial meningitis. We investigated whether systemic inflammation, in the absence of CNS infection, can lead to detectable CSF CRP and examined the roles of plasma...