Matthieu Martinet

Increased CSF PKR activation in Alzheimer’s disease is associated with APOE4 genotype

Abstract Objective Protein kinase R (PKR) is a stress-activated kinase implicated in translational control, neuroinflammation, and neurodegeneration. Although increased PKR activation was reported in Alzheimer’s disease (AD), prior studies relied on semi-quantitative methods. Thi...