Matthias P. Lütolf

Real‐Time Monitoring of Mass and Mechanical Properties in Single Cells and Multicellular Spheroids

ABSTRACT Cell state, growth, and mechanics are tightly connected properties underpinned by fundamental biological processes. Yet methods to quantify them simultaneously under physiologically relevant conditions, at resolutions sufficient to follow (sub)cellular processes, are sti...

Regulation of mRNA poly(A) tail length governs mammalian body plan formation in gastruloids

Abstract The establishment of the body plan during gastrulation represents a hallmark of animal life. It emerges from the interplay of gene-regulatory programs and positional cues, yet how these signals are integrated post-transcriptionally remains largely unexplored. Here, we co...