Matthias Mann

Scalable clinical proteomics from DNA/RNA extraction flowthroughs enables integrated proteogenomic profiling from a single cancer biopsy

Abstract Background Precision oncology has largely relied on genomic and transcriptomic sequencing to guide therapy selection in patients with advanced cancer. However, these molecular layers do not fully capture the functional state of tumors, as proteins largely represent the a...

Mechanosensitive phosphorylation of NFATC4 at S213/S217 drives fibroblast-to-myofibroblast transition and fibrosis

Mechanosensitive feedback between tissue stiffness and cellular contractile forces instructs cell identity. To characterize phosphorylation-mediated mechanosensing, we charted the global phosphoproteome dynamics of primary human lung fibroblasts on fibronectin-coated polydimethyl...

Leveraging Game-based and Blended Learning to Support Students with Heterogeneous Linguistic, Cultural, and Academic Backgrounds in a Lecture Series on Traffic Accident Biomechanics and Polytrauma Pathophysiology

A new international Master’s program in Biomedical Engineering, brings together students from diverse linguistic, cultural, and academic backgrounds with varying prior knowledge and learning needs. To support their entry into the sensitive topics of biomechanics and the pathophys...