Matthias Heinig

Community: Component based differential cell communication analysis in large multi-sample case-control scRNAseq datasets

Abstract Cell-cell communication is essential for physiological tissue function. In disease, communication often gets disbalanced by changes in the tissue cell type composition, fraction of cells engaged in communication, and changes in expression levels of ligands, receptors and...

Histological aging signatures for monitoring tissue-specific aging and disease

Aging is the primary risk factor for chronic disease and is characterized by profound structural and architectural remodeling of human tissues. Here, we present a comprehensive assessment of these changes using 25,712 whole-slide histopathological images from 40 tissue types acro...