Matthew Zimmerman

A Novel Chemotype of Orally Active SARS-CoV-2 NSP14 Methyltransferase Inhibitors

Abstract The periodic emergence of human coronaviruses (hCoVs) necessitates direct-acting antivirals targeting underexploited viral proteins with broad-spectrum potential. Building on our discovery of TDI-015051, a first-in-class SARS-CoV-2 mRNA cap guanine-N7 methyltransferase (...

Lesion penetration predicts tuberculosis treatment shortening through a validated translational tool to de-risk development

Abstract Anti-tuberculosis (TB) drugs must reach the disease site to be effective, but complex TB pathology limits drug distribution and efficacy, as bacteria in the necrotic center of lung cavities are difficult to access and kill. Our study generates the most comprehensive data...