Matthew W. Jones

Sleep as a window into thalamocortical pathology: generative modeling implicates NMDA receptor hypofunction in 22q11.2 deletion syndrome

Abstract 22q11.2 deletion syndrome (22q11.2DS) is a strong genetic risk factor for neuropsychiatric conditions, including schizophrenia, yet the underlying synaptic mechanisms remain unclear. Sleep EEG suggests thalamocortical dysfunction, but scalp data alone lack mechanistic re...