Matthew Lawrance

IL-2 mutein selectively expands thymic memory Tregs with increased transendocytosis activity in healthy participants

Tregs play an essential role in immune tolerance, and Treg-promoting therapies are in development for the treatment of many inflammatory disorders. Interleukin-2 (IL-2)-based therapies increase Treg frequency, but little is known about impacts on Treg heterogeneity and function....