Matthew James Smith

Conserved Core but Divergent Biochemical Features of RAS-MAPK Signalling in C. elegans

Genetic studies in Caenorhabditis elegans have established core principles of RAS-MAPK signalling. These nematodes encode three RAS proteins: LET-60/KRAS is essential for vulval induction, while RAS-1 and RAS-2 are orthologs of RRAS/RRAS2 and MRAS, respectively, but remain biolog...