Matthew J. Lazzara

Plectin promotes an aggressive phenotype and represses cytotoxic T cell activity in pancreatic cancer

Abstract Background Pancreatic adenocarcinoma (PDAC) is an abysmal disease, with a poor clinical outcome, largely due to limited life-extending treatments for patients. Notoriously, PDAC displays a T cell-suppressive tumor microenvironment where underlying molecular mechanisms th...