Matthew C. Lamb

Controlled Generation of Unstabilized N -Alkyl Nitrile Imines Enables Regioselective (3 + 2) Cycloadditions with Diverse Dipolarophiles

Abstract N-Alkyl nitrile imines remain underdeveloped as intermediates for intermolecular cycloadditions. Here, we report their in situ generation and regioselective (3 + 2) cycloaddition with activated and unactivated alkenes and alkynes, affording N-alkyl pyrazolines and pyrazo...

General C(sp3)–C(sp3)Cross-Coupling of Primary Amines via in Situ Diazene Formation

Abstract Primary amines are among the most abundant and readily available functional groups, yet their direct use as alkyl cross-coupling partners remains underdeveloped. We report a general platform for C(sp3)–C(sp3) cross-coupling enabled by the in situ formation and visible-li...