Matteo Fassan

Comprehensive Clinicopathologic, Immunohistochemical, and Genomic Profiling of Sporadic Ampullary Somatostatin-producing D-cell Neuroendocrine Tumors Identifies Recurrent HRAS Hotspot Mutations

Abstract Ampullary somatostatin-producing D-cell neuroendocrine tumors are rare neoplasms that may be associated with type 1 neurofibromatosis. The molecular features of sporadic ampullary somatostatin-producing D-cell neuroendocrine tumors (SAMSOM-NETs) remain poorly characteriz...

Subtotal colectomy with antiperistaltic caecorectal anastomosis versus total colectomy with ileorectal anastomosis for refractory slow-transit constipation: a comparative analysis

Abstract In selected cases of slow-transit constipation (STC), total colectomy with ileorectal anastomosis (TC-IRA) remains the standard surgical treatment but is associated with heterogeneous outcomes and relevant functional sequelae. Subtotal colectomy with caecorectal anastomo...