Mathias Müsken

Design, Synthesis, and Preliminary Investigation on the Mode of Action for a Series of Novel Antimicrobial Peptidomimetics

Abstract Over the years, many antibiotics have been developed, but most have become less effective due to antimicrobial resistance, especially those targeting enzymatic pathways. This growing resistance poses a serious global health threat. It is now recognized that physically di...

Arp2/3 complex-dependent actin remodeling is required for efficient RSV uncoating in A549 cells

ABSTRACT Productive human respiratory syncytial virus (RSV) cell entry requires coordinated interactions between viral proteins and host-cell factors at the plasma membrane-actin cortex interface. Branched actin networks remodel this interface, but their precise contribution to t...

Mechanistic insights into phage dynamics to overcome intracellular bacterial reservoirs in urinary tract infections

Abstract Recurrent urinary tract infections frequently arise from uropathogenic bacteria invading bladder epithelial cells, where they establish persistent intracellular reservoirs. Phages represent a promising therapeutic alternative to antibiotics owing to their host specificit...