Massimo Pizzato

SERINC5 is the primary target of retroviral antagonists among human SERINC paralogs and requires a tri-cysteine motif for its counteraction by HIV-1 Nef

The human transmembrane protein SERINC5 incorporates into budding HIV-1 particles and inhibits virus fusion with target cells. Although three other human SERINC paralogs display antiviral activity, their contribution to retroviral restriction and their susceptibility to viral ant...