Masayuki Nigo

Comparative adjuvant therapy to reduce vancomycin-associated nephrotoxicity in an animal model

Vancomycin is a mainstay antibiotic for serious gram-positive infections, but nephrotoxicity remains a major barrier to its optimal use. In this study, we compared the effectiveness of montelukast and zileuton as adjuvant strategies to reduce vancomycin-associated nephrotoxicity....