Masatoshi Hasegawa

Clinical Outcomes of Preoperative Hyperthermic Chemoradiotherapy for Locally Advanced Rectal Cancer

Background/Aim: We compared the clinical outcomes of preoperative hyperthermic chemoradiotherapy (HCRT) with outcomes after surgery alone in patients with locally advanced rectal cancer within 10 cm of the anal verge. Patients and Methods: We retrospectively evaluated 66 patients...

Differences in Biological Responses to Ultra-high Dose Rate Proton Irradiation Between Entrance and SOBP Regions In Vitro

Background/Aim: Ultra-high dose rate (FLASH) radiotherapy has been reported to reduce normal tissue toxicity while maintaining tumor control. However, whether proton FLASH induces different biological responses in the entrance versus spread-out Bragg peak (SOBP) regions under con...