Masami Otsuka

Structure-Function Study of Symmetrically Substituted Pyridine Derivatives Based on the Iron binding Site of Bleomycin

Abstract Symmetrical molecules were designed based on the bleomycin iron-binding site leading to an unexpected finding of a zinc-binding molecule SN-1. SN-1 and its derivatives inhibited/regulated zinc finger proteins HIV-EP1, farnesyltransferase, APOBEC3G, TRAF6, and ADAM17. HPH...