Masahiro Seike

Aberrant expression of the PREX2–MAGI2 axis modulates myofibroblast differentiation in pulmonary fibrosis

Myofibroblast differentiation is a pivotal event in idiopathic pulmonary fibrosis (IPF) and is driven by TGF-β1–dependent PTEN destabilization; however, the intermediate regulators remain incompletely defined. We tested three lung fibroblast cell lines (one normal and two IPF-der...