Mary P. Watson

Accessing Diverse C(sp3)-Rich Cyclophane Linkers in Macrocyclic Peptides via Nickel-Mediated Deaminative Macrocyclic Arylation

Abstract Within macrocyclic peptides of both natural products and pharmaceutical targets, aryl rings play a crucial role in linker structure, and C(sp3)-rich cyclophane linkers can imbue beneficial physicochemical properties. Yet, methods to deliver C(sp3)-rich cyclophane linkers...