Marleen de Bruijne

EXPRESS: Multidomain determinants of perivascular spaces indicate early cerebrovascular vulnerability in individuals at risk of Alzheimer’s disease

BACKGROUND: Perivascular spaces (PVS) are MRI-visible markers of cerebrovascular and glymphatic function, but their regional determinants in preclinical Alzheimer's disease (AD), regarding sex and AD biomarkers, remain poorly understood. METHODS: We studied 1,199 cognitively unim...

MRI-based shear stress profiles in subclinical carotid atherosclerosis – A feasibility study

Arterial wall shear stress (WSS) plays an important role in atherosclerosis, but its assessment is often limited to small, retrospective studies due to technical and time constraints. This study aimed to evaluate the feasibility of WSS assessment in carotid arteries within the lo...