Marko Lehtonen

Proteomics Reveals Blood−Brain Barrier Membrane Protein Remodeling in Amyloid-β Pathology

Abstract The protective function of the blood−brain barrier (BBB) is achieved by membrane proteins expressed in the endothelial cells of brain microvessels, such as tight junction proteins, receptors, and transporters, which regulate the passage of solutes, including nutrients, d...

Altered Membrane Protein Abundance in the Cerebral Cortex of the JNPL3 Mouse Model of Tauopathy

Abstract Developing effective therapeutic approaches for tau-associated neurodegenerative diseases, including frontotemporal dementia and Alzheimer’s disease, remains extremely challenging due to their complex pathogeneses. Membrane proteins constitute a large proportion of curre...