Mark WILKES

Mesenchymal stem cells in ribosomal insufficiency lead to aberrant osteoblastic differentiation and altered hematopoiesis

Diamond-Blackfan anemia (DBA) is an inherited bone marrow failure syndrome (IBMFS) characterized by macrocytic anemia. In addition to anemia, patients present with skeletal defects and an increased risk of osteosarcoma, suggesting dysregulated bone cell development. We found that...