Mark A. T. Blaskovich

Prophage and metabolic determinants of Staphylococcus aureus survival to vancomycin identified via TraDIS screening

ABSTRACT Reduced vancomycin susceptibility phenotypes in Staphylococcus aureus contribute to treatment failure, yet the genetic determinants of survival under inhibitory vancomycin exposure remain incompletely defined. We performed transposon-directed insertion-site sequencing (T...

Fragment-Based Explainable AI for Pathogen-Selective Antimicrobial Drug Design

Abstract The rise and extent of antimicrobial resistance demand computational tools that go beyond simple predictions of antimicrobial activity to deliver applicable medicinal chemistry insights for an accelerated and more efficient development of novel antimicrobials. Here, we p...