Mario L. Santiago

Interferome profiling in the blood links IFNα5-Mucin-1 axis to HIV-1 pathogenesis

ABSTRACT Type I interferons (IFN-Is) are essential for antiviral immunity, but contribute to immune dysfunction during chronic HIV-1 infection. IFN-Is comprise multiple IFNα subtypes that signal through a common receptor yet exhibit distinct biological activities, but their quali...