María S. Fernández‐Alfonso

Early kidney injury occurs in the absence of detectable perirenal adipose tissue remodelling in the Munich Wistar Frömter rat model of chronic kidney disease

Adipose tissue surrounding the kidney, known as perirenal adipose tissue (PRAT), is a metabolically active depot that may influence renal function through inflammatory and fibrotic mediators. In the Munich Wistar Frömter (MWF) rat, a genetic model of spontaneous chronic kidney di...

Hypertension in obesity: A focus on individualized pharmacotherapy and the role of body composition, on behalf of the European Society of Hypertension Working Group on Diabetes and Metabolic Risk Factors and Working Group on Lifestyle, Cardiovascular Pharmacotherapy and Adherence

Hypertension in obesity represents a major global health challenge, closely linked to the global epidemics of obesity, type 2 diabetes and metabolic dysfunction. Excess adiposity contributes to elevated blood pressure through multiple, interrelated mechanisms, including activatio...