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Cilastatin versus sodium thiosulfate for prevention of cisplatin-induced acute kidney injury during cytoreductive surgery with hyperthermic intraperitoneal chemotherapy (HIPEC): a randomized non-inferiority trial protocol

Cytoreductive surgery combined with hyperthermic intraperitoneal chemotherapy (CRS–HIPEC) using cisplatin is an established treatment for selected patients with peritoneal malignancies, but acute kidney injury (AKI) remains a common and clinically significant complication. Periop...