Margaret Anne Brimble

Synthesis of the N -Alkoxyguanidinyl Spiroketal Core of Rugonidines A–F

Abstract Rugonidines A–F are a family of structurally unique diastereomeric alkaloids characterized by an unprecedented [4.5]-fused N-alkoxyguanidinyl spiroketal ring system. This work reports the first synthesis of this motif via an acid-catalyzed, one-pot tandem deprotection/cy...