Marco Thomann

Evaluation and Optimization of Different DigestionStrategies for In-Depth Proteomic Characterization of Residual HostCell Proteins in rAAV-Based Gene Therapy Products

Abstract Recombinant adeno-associated virus vectors (rAAVs) are the most important vectors for in vivo gene therapies, yet their safety relies on low levels of residual host cell proteins (HCPs). While mass spectrometry-based proteomics enables sensitive and untargeted HCP profil...