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Trichlorination by a single cyanobacterial halogenase in the biosynthesis of lebomboamide A

Halogenation is a widely used strategy, both in nature and medicinal chemistry, to modulate the properties of small molecules. Cyanobacteria are a rich source of halogenases that act regio- and stereoselectively on sp3-hybridized carbon centers, which have been reported to cataly...