Márcia Machado Marinho

Integrated quantum chemical calculations and in silico approach to the anxiolytic effects of campesterol and its derivatives, with evaluation of locomotor activity in adult zebrafish (Danio rerio)

Abstract In this study, the anxiolytic and locomotor activity of campesterol and its seven derivatives were evaluated. The tests were analyzed using the zebrafish ( Danio rerio ) model. The animals were treated intraperitoneally ( i.p .) with the samples (4, 20, and 40 mg/kg in 2...

Molecular insights and ADMET profiling of iridoids as candidate leads for erectile dysfunction therapy

Abstract Context Erectile dysfunction (ED) significantly affects male psychosocial health and has an increasing incidence. Although phosphodiesterase 5 (PDEi-5) inhibitors are the first-line therapy, the occurrence of visual side effects resulting from cross-inhibition of the PDE...