Maosheng Cheng

Design, Synthesis, and Biological Evaluation of Novel Tetrazole-Containing Tetrahydroisoquinoline Derivatives as Putative CYP51 Inhibitors against Candida Species

Abstract To address the need for structurally diverse tetrazole-based CYP51 inhibitors with reduced CYP inhibition liability, we designed and synthesized a series of tetrazole-tetrahydroisoquinoline derivatives. Starting from the metabolically unstable lead A33 (t1/2 = 2.89 min),...

A Pathway-Economical Synthesis Enabling Systematic Evaluation: Enantiodivergent Access to Aspidosperma Alkaloids Unlocks Divergent Antitumor Mechanisms

Abstract The difficulty in efficiently accessing to both enantiomers has long hampered the systematic evaluation of how chirality governs the bioactivity of natural products. We report a pathway-economical synthesis that addresses this challenge, unlocking enantiodivergent access...

Design, Synthesis, and Biological Evaluation of Novel Arylethanone Oxime Ether Derivatives as Potent S1PR1 Agonists for Ulcerative Colitis Therapy

Abstract S1PR1 is a clinically validated key therapeutic target for ulcerative colitis (UC), but approved S1PR1 agonists universally suffer from the core drawback of S1PR3-mediated cardiotoxicity. Herein, we designed and synthesized multiple novel arylethanone oxime ethers-based...