Manabu Tokeshi

A Laminated Microfluidic Paper-Based Analytical Device Based on Image Analysis Using Optimized Color Space for Simultaneous Multiplexed Quantification of Chemical Water Quality Parameters

Abstract Water contamination remains a critical global challenge, underscoring the need for portable, low-cost, and user-friendly tools for on-site monitoring, particularly in resource-limited settings. This work presents a laminated multilayered wax-printed microfluidic paper-ba...

Non-destructive colocalization sensing of microRNAs and membrane proteins in single vesicles reveals spatial inflammation signatures

Chronic inflammation underlies a broad spectrum of diseases, yet current liquid biopsy approaches lack the spatial resolution and molecular specificity to detect localized, disease-specific inflammatory signals. Extracellular vesicles (EVs) offer a promising alternative, as they...