Makoto Bonkobara

Dual inhibition of PLK1 and CDK1/2 selectively suppresses the growth of canine squamous cell carcinoma cell lines with truncating TP53 mutations

Abstract Background Canine squamous cell carcinoma (SCC) remains a clinically challenging malignancy with limited therapeutic options for advanced or non-resectable cases. In this study, canine SCC cell lines harboring truncating TP53 mutations were identified, and TP53-associate...