Maggie J. Cox

TET2 loss triggers ssDNA gap accumulation and heightened PARP inhibitor sensitivity

Somatic mutations in the de novo methyltransferase DNMT3A and cytosine demethylase TET2 are common in age-related clonal hematopoiesis and hematopoietic neoplasms. TET2 mutations, unlike DNMT3A mutations, increase sensitivity to PARP inhibitors (PARPi). We find that TET2 loss, bu...

Unfolded protein response signaling promotes myeloid cell production and cooperates with oncogenic mutation

Abstract Unfolded protein response (UPR) promotes protein homeostasis under endoplasmic reticulum stress. UPR signaling has numerous functions in metabolism, cancer, immunology, and neurodegenerative diseases. Recent studies also showed that UPR signaling has important roles in h...