Madhu Ramesh

Differential detection of tau aggregation species using a small molecule probe for cell-based drug screening

Tau aggregation into polymorphic species, including oligomers, fibrils, and neurofibrillary tangles (NFTs), is central to the pathology of Alzheimer’s disease and related tauopathies. As an intrinsically disordered protein, tau undergoes liquid-liquid phase separation (LLPS), a m...

Guanidine-Functionalized Aminoglycosides Enable miR-7a Delivery to Attenuate Neuroferroptosis

Abstract Ferroptosis is an iron-dependent form of regulated cell death driven by lipid peroxidation and increasingly recognized as a key contributor to neurodegeneration (neuroferroptosis). Current pharmacological approaches primarily target downstream ferroptotic events and do n...