Madhavie Ranpati Dewage

Distinct tubulin C-terminal tails control the efficiency of a microtubule severing machine

Microtubule severing enzymes of the AAA+ family are essential regulators of cytoskeletal remodeling, extracting subunits from microtubules through Adenosine triphosphate (ATP)-driven conformational changes. Among them, katanin assembles into hexameric structures and binds the neg...