Maciej Masłyk

Trends and Future Directions in Organic Chemistry for Drug Discovery

ABSTRACT Organic chemistry sits at a pivotal moment. Two decades after combinatorial chemistry promised to industrialize molecule making, the field has converged on a far more interesting reality: medicinal chemists now operate at the intersection of new catalytic paradigms, biol...

Epigenetic Modulation by Luteolin, Quercetin and Apigenin in Systemic Lupus Erythematosus and Rheumatoid Arthritis: Mechanisms and Therapeutic Perspectives

For many years, plants have long served as sources of potential therapeutic agents. Recently, there has been a growing interest in investigating the effects of plant bio-active compounds on epigenetic modulation of several processes—among them, modifications of DNA, histones, and...

Growth Differentiation Factor-15 in Acute Coronary Syndromes: Prognostic Value and Barriers to Clinical Implementation

High-sensitivity cardiac troponin has made the diagnosis of myocardial infarction (MI) faster and more precise, but it does not measure the broader biological vulnerability that often determines the outcome after an acute coronary syndrome (ACS). Growth differentiation factor-15...