M.A. Karsdal

Collagen remodeling is elevated in fibrotic hypersensitivity pneumonitis and may distinguish it from idiopathic pulmonary fibrosis

Idiopathic pulmonary fibrosis (IPF) and fibrotic hypersensitivity pneumonitis (fHP) are two common causes of pulmonary fibrosis. Unlike IPF, fHP is caused by a persistent immune response to an antigen. Misclassification of fHP and IPF can lead to significant delays in antifibroti...

Circulating biomarkers reflecting type III, IV and VI collagen remodeling are present in lung tissue of patients with pulmonary fibrosis and non-fibrotic controls

Abstract Background The extracellular matrix (ECM) is a dynamic network that provides structural support and maintains tissue homeostasis. Collagens are the main structural components of the ECM, occupying distinct tissue compartments and serving specialized roles. Dysregulated E...